Recent Publications
On This Page
Heart Failure
Active researchers: Michael Fowler, Ron Witteles, Euan Ashley, Randy Vagelos, Mike Pham
Witteles RM, Fowler MB. Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options. J Am Coll Cardiol. 2008;51:93-102
Ashley EA, Ferrara R, King JY, Vailaya A, Kuchinsky A, He X, Byers B, Gerckens U, Oblin S, Tsalenko A, Soito A, Spin JM, Tabibiazar R, Connolly AJ, Simpson JB, Grube E, Quertermous T. Network analysis of human in-stent restenosis. Circulation. 2006; 114:2644-54.
Witteles RM, Kao D, Christopherson D, Matsuda K, Vagelos RH, Schreiber D, Fowler MB. Impact of nesiritide on renal function in patients with acute decompensated heart failure and pre-existing renal dysfunction a randomized, double-blind, placebo-controlled clinical trial. J Am Coll Cardiol. 2007; 50:1835-40
deGoma EM, Vagelos RH, Fowler MB, Ashley EA.
Emerging therapies for the management of decompensated heart failure: from bench to bedside. J Am Coll Cardiol. 2006 Dec 19;48(12):2397-409. Epub 2006 Nov 28. Review.
Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW, Antman EM, Smith SC Jr, Adams CD, Anderson JL, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B; American College of Cardiology; American Heart Association Task Force on Practice Guidelines; American College of Chest Physicians; International Society for Heart and Lung Transplantation; Heart Rhythm Society.
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the Int
Basic Science/ Vascular Biology
Active researchers: Tom Quertermous, Phil Tsao, John Cooke, Joe Wu, Gerald Reaven, C.P. Chang, Dan Grief, Patrick Yue, Euan Ashley, Josh Spin, Roger Wagner,
Sheikh AY, Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D, Hendry SL, Wagner RA, Chen MM, Ali ZA, Yue P, Huynh DT, Connolly AJ, Pelletier MP, Tsao PS, Robbins RC, Quertermous T. In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Jan;294(1):H88-98.
Wu H, Kao SC, Barrientos T, Baldwin SH, Olson EN, Crabtree GR, Zhou B, Chang CP.
Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.
J Biol Chem. 2007 Oct 19;282(42):30673-9. Epub 2007 Aug 10.
Xie X, Cao F, Sheikh AY, Li Z, Connolly AJ, Pei X, Li RK, Robbins RC, Wu JC.
Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function.Cloning Stem Cells. 2007 Winter;9(4):549-63.
Quertermous T.
Apelin and its g protein-coupled receptor regulate cardiac development as well as cardiac function.Dev Cell. 2007 Mar;12(3):319-20.
Wilson AM, Kimura E, Harada RK, Nair N, Narasimhan B, Meng XY, Zhang F, Beck KR, Olin JW, Fung ET, Cooke JP. Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies.Circulation. 2007;116:1396-403.
Ardigo D, Assimes TL, Fortmann SP, Go AS, Hlatky M, Hytopoulos E, Iribarren C, Tsao PS, Tabibiazar R, Quertermous T; ADVANCE Investigators.
Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease.Physiol Genomics. 2007 Nov 14;31(3):402-9. Epub 2007 Aug 14.
Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP.Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis.Dev Cell. 2008 Feb;14(2):298-311.
Ashley E, Chun HJ, Quertermous T.
Opposing cardiovascular roles for the angiotensin and apelin signaling pathways.
J Mol Cell Cardiol. 2006 Nov;41(5):778-81. Epub 2006 Sep 26.
Fearon WF, Shah M, Ng M, Brinton T, Wilson A, Tremmel JA, Schnittger I, Lee DP, Vagelos RH, Fitzgerald PJ, Yock PG, Yeung AC. Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction.
J Am Coll Cardiol. 2008;51:560-5.
Ashley EA, Ferrara R, King JY, Vailaya A, Kuchinsky A, He X, Byers B, Gerckens U, Oblin S, Tsalenko A, Soito A, Spin JM, Tabibiazar R, Connolly AJ, Simpson JB, Grube E, Quertermous T.
Network analysis of human in-stent restenosis.Circulation. 2006 Dec 12;114(24):2644-54. Epub 2006 Dec 4.
Creager MA, Cooke JP, Olin JW, White CJ; Society for Cardiovascular Angiography and Interventions; Society for Vascular Medicine.
Task force 11: training in vascular medicine and peripheral vascular catheter-based interventions endorsed by the Society for Cardiovascular Angiography and Interventions and the Society for Vascular Medicine.
J Am Coll Cardiol. 2008 Jan 22;51(3):398-404.
Fearon WF, Tonino PA, De Bruyne B, Siebert U, Pijls NH; FAME Study Investigators.
Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study.Am Heart J. 2007 Oct;154(4):632-6. Erratum in: Am Heart J. 2007 Dec;154(6):1243.
Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S.Introducing the first polymer-free leflunomide eluting stent.
Atherosclerosis. 2008 Feb 22
Imaging (Molecular Imaging)
Active Researchers: Joe Wu, Mike McConnell, David Liang, Paul Heidenreich, Ingela Schnittger, Phil Yang.
Tsukiji M, Nguyen P, Narayan G, Hellinger J, Chan F, Herfkens R, Pauly JM, McConnell MV, Yang PC.
Peri-infarct ischemia determined by cardiovascular magnetic resonance evaluation of myocardial viability and stress perfusion predicts future cardiovascular events in patients with severe ischemic cardiomyopathy.
J Cardiovasc Magn Reson. 2006;8(6):773-9.
Yue P, Arai T, Terashima M, Sheikh AY, Cao F, Charo D, Hoyt G, Robbins RC, Ashley EA, Wu J, Yang PC, Tsao PS.Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse.
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2106-18.
de la Pena E, Nguyen PK, Nayak KS, Yang PC, Rosenthal DN, Hu BS, Pauly JM, McConnell MV.
Real-time color-flow CMR in adults with congenital heart disease.
J Cardiovasc Magn Reson. 2006;8(6):809-15.
Cardiac Transplantation
Active Researchers: Sharon Hunt, Mike Pham, Hannah Valentine, Francois Haddad
Hunt SA.
Taking heart--cardiac transplantation past, present, and future.
N Engl J Med. 2006 Jul 20;355(3):231-5. No abstract available. Erratum in: N Engl J Med. 2006 Aug 31;355(9):967.
Fearon WF, Hirohata A, Nakamura M, Luikart H, Lee DP, Vagelos RH, Hunt SA, Valantine HA, Fitzgerald PJ, Yock PG, Yeung AC.
Discordant changes in epicardial and microvascular coronary physiology after cardiac transplantation: Physiologic Investigation for Transplant Arteriopathy II (PITA II) study.
J Heart Lung Transplant. 2006 Jul;25(7):765-71. Epub 2006 May 24.
Albert CM, Rosenthal L, Calkins H, Steinberg JS, Ruskin JN, Wang P, Muller JE, Mittleman MA; TOVA Investigators. Driving and implantable cardioverter-defibrillator shocks for ventricular arrhythmias: results from the TOVA study. J Am Coll Cardiol. 2007;50:2233-40.
Engel G, Cho S, Ghayoumi A, Yamazaki T, Chun S, Fearon WF, Froelicher VF.
Prognostic significance of PVCs and resting heart rate.
Ann Noninvasive Electrocardiol. 2007 Apr;12(2):121-9.
Anh DJ, Eversull CS, Chen HA, Mofrad P, Mourlas NJ, Hardwin Mead R, Zei PC, Hsia HH, Wang PJ, Al-Ahmad A.
Characterization of Human Coronary Sinus Valves by Direct Visualization during Biventricular Pacemaker Implantation.
Pacing Clin Electrophysiol. 2008 Jan;31(1):78-82.
Genetic Cardiology
Active researchers: Tim Assimes, Josh Knowles, Tom Quertermous, Mark Hlatky, Josh Spin
Assimes TL, Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibiazar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatky MA, Fortmann SP, Myers RM, Kuhn H, Risch N, Quertermous T. A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.Atherosclerosis. 2007 Oct 22; [Epub ahead of print
Hlatky MA, Ashley E, Quertermous T, Boothroyd DB, Ridker P, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS; Atherosclerotic Disease, Vascular Function and Genetic Epidemiology (ADVANCE) Study. Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. Am Heart J. 2007;154:1043-51.
Knowles JW, Wang H, Itakura H, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS, Quertermous T, Hlatky MA.
Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. Am Heart J. 2007 Dec;154(6):1052-8.
Assimes TL, Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibiazar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatky MA, Fortmann SP, Myers RM, Kuhn H, Risch N, Quertermous T.
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.Atherosclerosis. 2007 Oct 22;
Exercise Physiology
Active researchers: Vic Froelicher, Jon Meyers, Euan Ashley
Dewey FE, Kapoor JR, Williams RS, Lipinski MJ, Ashley EA, Hadley D, Myers J, Froelicher VF.
Ventricular arrhythmias during clinical treadmill testing and prognosis.
Arch Intern Med. 2008 Jan 28;168(2):225-34.
Leeper NJ, Dewey FE, Ashley EA, Sandri M, Tan SY, Hadley D, Myers J, Froelicher V. Prognostic value of heart rate increase at onset of exercise testing. Circulation. 2007 30;115:468-74. Gupta MP, Polena S, Coplan N, Panagopoulos G, Dhingra C, Myers J, Froelicher V.Prognostic significance of systolic blood pressure increases in men during exercise stress testing. Am J Cardiol. 2007 Dec 1;100(11):1609-13. Epub 2007 Oct 23.
Leeper NJ, Ardehali R, deGoma EM, Heidenreich PA. Statin use in patients with extremely low low-density lipoprotein levels is associated with improved survival.
Circulation. 2007;116:613-8.
Bravata DM, Gienger AL, McDonald KM, Sundaram V, Perez MV, Varghese R, Kapoor JR, Ardehali R, Owens DK, Hlatky MA.
Systematic review: the comparative effectiveness of percutaneous coronary interventions and coronary artery bypass graft surgery.Ann Intern Med. 2007 Nov 20;147(10):703-16. Epub 2007 Oct 15. Review.
deGoma EM, Leeper NJ, Heidenreich PA. Clinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol.
J Am Coll Cardiol. 2008; 51:49-55.
Heidenreich PA, Gholami P, Sahay A, Massie B, Goldstein MK.
Clinical reminders attached to echocardiography reports of patients with reduced left ventricular ejection fraction increase use of beta-blockers: a randomized trial.
Circulation. 2007 Jun 5;115(22):2829-34. Epub 2007 May 21.
Stem Cell Biology
Active researchers: Phil Yang, Bobby Robbins, Joe Wu, Irv Weissman, Reza Ardehali, etc
Rodriguez-Porcel M, Brinton TJ, Chen IY, Gheysens O, Lyons J, Ikeno F, Willmann JK, Wu L, Wu JC, Yeung AC, Yock P, Gambhir SS. Reporter gene imaging following percutaneous delivery in swine moving toward clinical applications. J Am Coll Cardiol. 2008;51:595-7
Sheikh AY, Lin SA, Cao F, Cao Y, van der Bogt KE, Chu P, Chang CP, Contag CH, Robbins RC, Wu JC.
Molecular imaging of bone marrow mononuclear cell homing and engraftment in ischemic myocardium.
Stem Cells. 2007 Oct;25(10):2677-84. Epub 2007 Jul 12.
Li Z, Suzuki Y, Huang M, Cao F, Xie X, Connolly AJ, Yang PC, Wu JC.
Comparison of Reporter Gene and Iron Particle Labeling for Tracking Fate of Human Embryonic Stem Cells and Differentiated Endothelial Cells in Living Subjects.
Stem Cells. 2008 Jan 24;
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL.
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007 Jun 7;447(7145):725-9
Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC.
Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation. 2007 Sep 11;116(11 Suppl):I46-54.
Insulin Resistance
Active researchers: Gerald Reaven, Patrick Yue, Phil Tsao
Martin M, Palaniappan LP, Kwan AC, Reaven GM, Reaven PD. Ethnic Differences in the Relationship between Adiponectin and Insulin Sensitivity in South Asian and Caucasian Women. Diabetes Care 2008 Jan 17; [Epub ahead of print]
Yue P, Arai T, Terashima M, Sheikh AY, Cao F, Charo D, Hoyt G, Robbins RC, Ashley EA, Wu J, Yang PC, Tsao PS. Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse.
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2106-18. Epub 2006 Nov 22.
Sydow K, Mondon CE, Schrader J, Konishi H, Cooke JP.
Dimethylarginine Dimethylaminohydrolase Overexpression Enhances Insulin Sensitivity.
Arterioscler Thromb Vasc Biol. 2008 Jan 31;