Endothelial Biology
The Cooke Lab
Our interest is the role of the endothelium in atherosclerosis and in angiogenesis. We are particularly interested in the action of endothelium-derived nitric oxide, and derangements in the nitric oxide synthase pathway that cause vascular disease.
Dysfunctional Endothelial Cell in Dyslipidemia and Atherosclerosis
The research program is vertically integrated from molecule to man, using molecular and cell biological tools, animal models of vascular disease, and vascular imaging and physiologic testing.
Ongoing studies include:
Basic Research:
ADMA: An endogenous inhibitor of NO synthase
Role of NO in Angiogenesis
Role of NO in atherosclerosis
Nicotine is an Agent of AngiogenesisClinical Studies:
The NO PAIN study
The Genomics of PAD
Patients, for more information about NO PAIN click here.
Doctors, for more information about NO PAIN click here.
Members of Cooke's Lab
From
Left:
Vinod Achan,
Scott Reiff ,
Markus Stuehlinger,
John Cooke,
Chris Heeschen,
Sundar Sankaran,
Michael Weis,
Om Kapoor,
Roberta Oka,
Andrzej Szuba